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This work is supported by the National Key Research & Development Program (2022YFC2603900), Beijing Natural Science Foundation (JQ24055), and the National Natural Science Foundation of China (22175189, 52373127)

Clinical trial results In phase 3 trials, average weight loss over 68 weeks was: 20.4% with CagriSema 14.9% with semaglutide alone 11.5% with cagrilintide alone 3% with placebo Side effects were mostly mild to moderate, similar to current GLP-1s

Someone with a genetic variant that reduces GLP-1 receptor expression may require higher doses or longer treatment periods to achieve similar results as someone with typical receptor function

These solutions' market penetration in Germany helps regional clinical research organizations (CROs) with their clinical research trials and assures managerial simplicity, which speeds up the discovery process

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Most of the studies have shown its therapeutic role in melasma, whereas some studies have contradicted this fact[] [Table 1]