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However, adaptation is not universal

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Some patients taking this medication may have thoughts of suicide or self-harm

However, despite the clinical evidence that serum E2 levels are inversely correlated with psoriasis severity, and replacement therapy with low-dose E2 administration in may improve psoriasis, tamoxifen, an antiestrogen agent, results in the remission of psoriasis, thus suggesting that estrogens might exert both pro-inflammatory and anti-inflammatory effects in psoriasis [124]

More than predicted