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Conformational rigidity: MT-II is conformationally constrained by the 23-membered lactam ring, which pre-organizes the pharmacophore (His-D-Phe-Arg-Trp) into a defined spatial arrangement

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Interestingly, a coronatine-deficient mutant bacterium caused only mild symptoms but consistently induced 2- to 5-times higher GST transcript levels than the coronatine-producing wild type strain

According to the American Academy of Dermatology, up to 50% of scalp hair follicles can shift to the telogen phase during a telogen effluvium episode, resulting in noticeable diffuse shedding across the entire scalp rather than in localized patches

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pH 7.4 with NaOH