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32 Zinc acts as a cofactor for enzymes of the antioxidant system, and inhibits the enzyme, nicotinamide adenine dinucleotide phosphate oxidase, a prooxidant enzyme, and induces metallothionein synthesis, which is important in the reduction of hydroxyl radicals

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Net effect: twice-weekly splitting delivers similar peak reduction in both compounds (around 28%), but the absolute smoothing benefit is slightly smaller for retatrutide because the starting curve is already flatter

However, even if a patent lapses, it may still be reinstated under certain conditions, which can complicate determinations of enforceability