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Lopez-Siles M, Khan TM, Duncan SH, Harmsen HJ, Garcia-Gil LJ, Flint HJ

10.1128/mcb.17.7.3556 108 StokerM.GherardiE.PerrymanM.GrayJ

Stopping phentermine while continuing semaglutide is generally the safer approach, as semaglutide demonstrates better long-term safety data and weight loss durability

While their mechanisms differ, combining them amplifies cardiovascular strainelevated blood pressure, tachycardia, and arrhythmia risk increase substantially when both drugs are active

Individuals with active cancer or a history of malignancy should avoid the peptide unless under medical supervision, as effects on tumor growth have not been adequately studied

They may be able to help you figure out a different dosing schedule that doesnt make getting a good nights sleep too difficult