This effect is minimal over 2-3 weeks but can become relevant for vials kept for longer periods
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and 4 is defined as hypertonic flexor and extensor muscles [3]
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The ligands were bound to D106 according to the crystal structures using the [intermolecular_interactions] block of GROMACS with a bond length of 0.185 nm, a force constant of 10 5 kJ mol 1 nm 2 and bond type 6