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A short pause can teach you more than a long restriction

The additive insulinotropic effect of GIP combined with GLP-1 results from direct beta-cell stimulation and enhancement of alpha-to-beta cell paracrine communication, with GIP contributing substantially to postprandial insulin secretion [30,31]

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If irritation appears, the first step is usually to reduce frequency or pause use, allow the skin to recover, and reintroduce cautiously