30,31,32 The coatomer subunit gene mutations could disrupt the endoplasmic reticulum (ER)Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis, thereby providing a connection between the lung and the joint diseases
A.Carrasco-MarinF.BetancurS.Bailn-GarcaE.et al (2024)
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FIGURE 10 The excipients only exert their activity at high concentration, which means that, while they are able to prevent proteolysis as soon as they are released from the capsule, peristaltic action and dilution with luminal fluid result in reduction of their inhibitory activity after a certain time windowprobably no longer than 30 minutes
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