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This was achieved by demethylating the promoters of 14-3-3, CHK2 and DAPK-1 genes, promoting the expression of these genes, and then activating the G2/M checkpoint response in osteosarcoma cells, to improve the radiotherapy effect of osteosarcoma 10 (Figure 1 and Table 1)

Proteomics analysis of the gut-brain axis in a gut microbiota-dysbiosis model of depression

Suspected side effects can be reported via the MHRA Yellow Card Scheme

From the clinical trials conducted so far, changes in the tumor size or recurrence were infrequent, but further assessment needs to be carried out

No significant toxicity has been identified in animal studies even at doses far exceeding typical human protocols

EMBO J 2002, 21: 4229-4239