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Castanedo-Cazares JP, Hernandez-Blanco D, Carlos-Ortega B, Fuentes-Ahumada C, Torres-lvarez B

258,259 In gout, the activation of the NLRP3 inflammasome by monosodium urate (MSU) crystals stimulates the release of IL-1, which contributes to the progression of arthritis

However, in a small human study, taking Baikal skullcap extract did not enhance the antidiabetic effects of metformin, although it did modestly lower glucose levels during an oral glucose tolerance test (OGTT)

10.1152/ajprenal.1999.277.4.F493 54 PlaitakisA.MetaxariM.ShashidharanP

Glia 64, 12981313

The science supports itespecially in cases where pigmentation and oxidative damage are the root causes