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One of the outcomes observed from meta-analysis prescribed administration of probiotics to be associated with a considerable decline in risk of mortality, although this observation holds only for female animals

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These concerns first gained prominence around 20112013, when regulatory agencies began investigating potential pancreatic safety signals associated with incretin-based therapies, including both GLP-1 receptor agonists and DPP-4 inhibitors

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GLP-1 receptors are abundantly expressed in the pancreas, intestine, and central nervous system