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Geniposide, acting as a GLP-1R agonist, partially prevented STZ-induced learning and memory impairment via modulation of PI3K/GSK-3 signaling pathway and reduced STZ-induced hyperphosphorylation of tau protein (220)
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Although its uncertain what caused these conflicting results, all these clinical trials suffered from flaws such as small sample sizes and short duration
A growing body of evidence suggests that GLP-1 has anti-inflammatory actions independent of its metabolic actions
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