Currently, we have a poor understanding of how sea urchins can maintain this downregulated state for periods of years when other marine invertebrates, such as abalone undergo complete starvation (no kelp provided) for up to 13 months before mortality occurs 30
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Additionally, mitochondrial dysfunction in AT under obese conditions can significantly increase respiration and biogenesis, promote fatty acid oxidation and alter metabolism, all of which lead to the production of excess acetyl-CoA (77, 78)
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This might involve a lower daily dosage administered for 6 months, followed by a 2-3 month break
