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Three MARA domains are material: Clinical Effectiveness (exceptional efficacy, unresolved cardiovascular safety signal), Comparator Selection (retatrutide will be assessed against tirzepatide, not placebo), and HRQoL (higher side effect burden may narrow access relative to established alternatives)
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(free version for non-subscribers) Posted on February 18, 2026
10.1080/15548627.2020.1810918 17 ChengY.LuoR.WangK.ZhangM.WangZ.DongL.et al (2020)
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