Classic sign of oxidative copper dissociation
However, this approach is not routine first-line treatment in UK practice, is considered off-label, and requires good patient adherence and clinical follow-up
Hydroquinone and other skin lighteners work for those with dark pigmentation under their eyes (although do seek a doctors opinion first because usually darkness under the eyes is actually very thin skin with blood vessels showing through it and lightening agents will not help, but could hurt thin skin) 5
Patient Variation in Pernicious Anaemia, as Shown in a Clinical Trial of Cyanocobalamin, Hydroxocobalamin and CyanocobalaminZinc Tannate Variation between patients makes it impossible to anticipate the duration of effect of a single injection of one of these drugs in any patient
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Deamidation proceeds faster at higher temperatures and represents a major stability concern for peptides stored at room temperature for extended periods