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Based on the results of previous studies showing increases in muscle performance [9,10,11, 17] in response to a single 8-g dose of L-citrulline malate, it can be assumed that longer durations of L-citrulline supplementation might bestow ergogenic effects

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Your body is adjusting to increasing levels of GLP-1 receptor activation, and the first few days after each dose increase tend to be the roughest