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The effects of ER once-weekly have been compared to exenatide twice-daily and overall ER was more effective at improving glycemic control and caused less gastrointestinal side-effects although both compounds caused a similar degree of weight loss (Drucker et al., The efficacy of once-weekly ER (2 mg) was compared to that of once-daily liraglutide (1.8 mg) in a 26-week trial in T2DM patients (Buse et al., DPP-4 inhibitors The DPP-4 inhibitors mediate their action by inhibiting the enzyme DPP-4, which prevents the breakdown of GLP-1 and thereby increases endogenous GLP-1 levels
The distinction matters, both biologically and in terms of safety
Additionally, discuss any history of pancreatitis, diabetic retinopathy, or kidney disease, as these conditions may require closer monitoring during treatment
Cong, et al., 'Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide', Cell Discov
Serious risks include birth defects during pregnancy
Metabolism: Clinical and Experimental, 60 (6), 749-753
