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However, in view of the excellent safety profile of B12, even at high doses, supplementation, ideally as part of a more comprehensive nutritional programme, may still be of value when the clinical picture and/or other factors (e.g

B12 is generally considered safe in all life stages even at high doses and there are no known interactions with any medications, but some drugs can increase the risk of B12 deficiency, including acid-lowering drugs and metformin