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Increase fullness Reduce hunger Slow down stomach emptying Support insulin release after meals (especially helpful in type 2 diabetes) Which oral GLP-1 drugs are available
As a transformative therapeutic modality, retatrutide represents a beacon of hope, signifying transformative changes in the management landscape of obesity and type 2 diabetes mellitus (T2DM), and warranting continued exploration and refinement in clinical practice
The dual mechanism of tirzepatide tends to produce greater weight loss in clinical trials, approximately 20% to 25% body weight reduction compared to 15% to 17% for semaglutide at maximum doses
My advice to clinicians is to proactively discuss contraception when initiating GLP-1 therapies in women of child-bearing age, document pregnancy intentions, and give pre-conception wash-out advice as per FSRH guidelines, said Dr Cheung
2009;32(Suppl 2):S15763
Pros Strongest raw-material traceability in the comparison
