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Heavy or daily drinking, however, compromises both the copper homeostasis system and the wound-healing pathways that GHK-Cu activates (alcohol impairs fibroblast migration and collagen synthesis independently of copper status) [9]
When folate cycling is impaired by MTHFR insufficiency, the dihydrofolate THF step accumulates dihydrofolate, competing with the BH2 BH4 reduction step for DHFR activity and NADPH
Wound healing and angiogenesis GHK-Cu has been studied extensively in wound healing contexts
