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They are for information purposes only and should not be construed as a substitute for professional medical advice
Retatrutide is a next-generation triple receptor agonist that simultaneously activates three distinct hormonal pathways involved in appetite regulation, metabolic efficiency, and energy expenditure: GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors
GLP-1 medications like semaglutide work by mimicking the action of the GLP-1 hormone, a type of incretin hormone that is produced in the gut and helps stimulate insulin secretion after you eat
The injection makes patients feel fuller, so they consume fewer calories
This prior exposure may slightly blunt the initial appetite-suppressing effects of retatrutide GLP-1 component, though the additional GIP and glucagon pathways will still be novel
Current patient education on GLP-1 RAs emphasizes adequate protein intake, primarily to preserve muscle mass, while giving less attention to dietary fiber, despite its important roles in satiety, glycemic control, and gut microbiome health
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