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This underscores the importance of identifying additional clinical or biological factors that can better predict glycaemic response to GLP-1 RA treatment
expounded on the obesity paradox, suggesting increased BMD is offset by poor bone quality due to advanced glycation end-products (AGEs) accumulation, impaired osteoblast function, and uncoupled bone turnover favoring resorption
PMID: 19570099
However, data from clinical trials suggest the following: People with diabetes who take a GLP-1 peptide in addition to diet and exercise changes can expect to lose 4% to 6% of their body weight
Two modalities have emerged as particularly promising for this balanced approach: injectable BPC-157 peptide therapy and strategic cold exposure through cryotherapy
5: Rahman OF, Lee SJ, Seeds WA
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