Cold sensitivity is not listed as a direct adverse effect in FDA prescribing information, but patients commonly report it as an indirect consequence of significant weight loss
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My suspicion is that most people regain the weight because the treatment was short-term, focused on weight loss rather than developing better habits, and resulted in loss of muscle, which reduces your basal metabolic rate and makes you more likely to gain weight
Orfoglipron, a once-daily oral molecule, remains in successful late-stage development