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Diet is absolutely critical, both in caloric load and macronutrient balance
Furthermore, owing to its narrow therapeutic index and large PK/PD variability, administering an initial busulfan IV dose based only on body weight (WT) may result in failure to reach the target therapeutic window (Ben Hassine et al., 2021
Plasma free-carnitine levels rise within minutes of an intravenous dose, and many patients report improved energy or reduced muscle fatigue within days to a few weeks once tissue stores are replenished
Perhaps most importantly, individuals with malabsorption issues may take oral supplements faithfully yet remain deficient, wasting money and time while symptoms persist
Holmay M, et al
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