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For example: Tirzepatide (Zepbound) shows the greatest mean weight loss and is also approved for obstructive sleep apnea, but semaglutide (Wegovy) is preferred for those with cardiovascular or kidney complications or metabolic-associated steatohepatitis (MASH) due to broader FDA approvals

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Sitagliptin and vildagliptin are not licensed for use in renal impairment, whereas saxagliptin can be used at a reduced dose and linagliptin can be used at the only strength available