The study showed that an interruption of GLP-1 use of just 6 months before resuming treatment was enough to significantly decrease the cardiovascular benefit
continued using Bmal1 knockout mice and reported altered clock gene expression (Cry2 and Per2) along with decreased Nrd1, Dbp, Il1 , and Nox2 expression and increased Gsr and Lpl expression, indicating that Bmal1 regulates immune response and cellular metabolism in microglia (Wang et al., 2020)
Immunity 40 , 692705 (2014)
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GLP-1 receptor (GLP-1R) agonists modulate enteric immune responses through the intestinal intraepithelial lymphocyte (IEL) GLP-1R