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International Journal of Clinical and Health Psychology, [online] 22(1), p.100279
Making sense of early high-dose intravenous vitamin C in ischemia/reperfusion injury
These processes play key roles to promote chemoresistance in tumors, where elevated GSH inactivates electrophilic chemotherapeutic agents (cisplatin, alkylators), GSTs enable drug conjugation, and MRP-catalyzed efflux reduces intracellular drug levels - while inhibiting therapy-induced oxidative stress at the same time
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