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By increasing resting energy expenditure through thermogenesis and fat oxidation, retatrutide may promote preferential fat loss while relatively sparing lean mass
Cost differences reflect these functional differences rather than quality alone
That gap is the question this article addresses: not just how large it is, but why it exists, whether it matters clinically, and what it means for someone already on semaglutide today
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The most common adverse effects of retatrutide were gastrointestinal (GI) such as nausea, diarrhea, vomiting and constipation reported by 13-50% in the retatrutide groups compared with 35% in the dulaglutide group, and 13% in the placebo group
The risk of muscle loss is particularly pronounced in certain populations: older adults (age 65+) who already face age-related sarcopenia, sedentary individuals without resistance training stimulus for muscle preservation, and patients losing weight very rapidly
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