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In addition, as for DRG cells, NF-E2-related factor 2 (Nrf2) that upregulates the expression of antioxidant enzymes (e.g., SOD, CAT, and glutathione-S-transferase (GST)) to eliminate oxidative stress, would be disrupted by accumulated Pt drugs (Dos Santos et al., 2021)

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This evaluation reviews current health status, lab work, medications, and the patients specific goals to determine which combination makes clinical sense

However, the compound is not included in IV therapy treatment directly

On the other hand, Se can decrease the production of ROS and nitric oxide by modulation of p38 mitogen-activated protein kinase and NF-kB signaling pathways [84]

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