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The most robust evidence to date comes from the phase 2 randomised controlled trial (Jastreboff et al., NEJM , 2023)

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Permeability to proteins and to large lipoid molecules

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Treatment with Fer-1 effectively inhibited ferroptosis and significantly alleviated fibrotic changes in these cells

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Weissman JR, Kelley RI, Bauman ML, Cohen BH, Murray KF, Mitchell RL et al

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Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update

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Notably, Zhang et al

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