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December 22, 2025

Evidence from Patients with Diabetes The independence of cardiovascular benefit from weight loss extends to patients with type 2 diabetes as well

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Introduction Glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotransporter-2 (SGLT-2) inhibitors are second to third line antihyperglycaemic drugs commonly prescribed for the treatment of type 2 diabetes.12 Individually, these drugs have been shown to reduce the risk of cardiorenal events and mortality in large cardiovascular outcome trials.3456789 However, the combined effect of these drug classes on these outcomes has not been extensively studied

A more selective compound may be easier to interpret, but it may not be the best fit for every research model