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Straus cited the "widespread use of chelation therapy in lieu of established therapies, the lack of adequate prior research to verify its safety and effectiveness, and the overall impact of coronary artery disease" as factors motivating the trial

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Radix Paeoniae Alba (white peony root) is the dried root of *Paeonia tactilora* Pall

Nature 526 , 666671 (2015)

Hormonal factors: Conditions like PCOS or hormonal fluctuations can influence melanin production independently of supplementation, sometimes making the net visible change slower to emerge

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