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Aggregated protein is both less active and potentially immunogenic
At the enzyme level, 5-Amino-1MQ inhibits NNMTs methylation of nicotinamide reducing intracellular 1-MNA levels and diverting nicotinamide back into the NAD+ salvage pathway (via NAMPT-mediated conversion to NMN and subsequently NAD+)
Journal of Biomolecular Structure and Dynamics, 42(2), 115
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