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It is triggered by damage to the retinal pigment epithelium (RPE) of the eye resulting in overall blurred vision as well as loss of vision in the centre of the eye

Jan 2012;28(1):20-24

Research indicates that individuals with BP-I remain symptomatic for nearly half of their illness course, with depressive symptoms being the most frequent and persistent, significantly outweighing manic/hypomanic and mixed episodes (Nierenberg et al., 2023)

At the brain, different neural circuits receive activation signals through both receptor types, creating broader coverage of appetite-regulating regions

Zhong Xi Yi Jie He Xue Bao 9 (11), 11791184

While surveying the literature in preparation of this manuscript we have also noticed and reported an increasing interest in the role that GSTs play in neurodegeneration, where isozymes belonging to the family may be either up-regulated, mutated or absent, according to the different diseases