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Sitagliptin, a dipeptidyl peptidase-4 inhibitor, was selected as an active-comparator placebo proxy because it was recommended in clinical guidelines as a second-line glucose-lowering therapy, had a similar high cost to the study drugs, showed no effect on cardiovascular outcomes in a large randomized controlled trial and has been validated as a placebo proxy in prior claims-based research 20,41
It does not directly dissolve fat or selectively remove fat from the stomach, thighs or another specific body area
Immunology 172, 451468
Individual Variability : Factors such as age, overall health, and the presence of other medical conditions can significantly influence an individuals response to B12 deficiency treatment, as well as the duration of their recovery
Gut motility and intestinal barrier integrity are two major components of IBS, which are affected by both FODMAPs and GLP-1
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