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New data from a massive cohort study of 2 million patients published in Nature Medicine in January 2025, suggest that GLP-1 medications may actually reduce the risk of substance use disorders , including Cannabis Use Disorder (CUD)
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The development of peptide-based drugs themselves has received increasing attention compared to the development of delivery modes and vaccines (Fig
Retatrutide is a weight loss treatment in development and is not licensed in the UK
Overview of main clinical studies for MASLD/MASH with GLP-1 receptor agonists and dual or triple agonists targeting glucagon/GIP/GLP-1 receptors Liraglutide Liraglutide, a once-daily GLP-1 receptor agonist with authorized indications for type 2 diabetes and obesity, was evaluated in the LEAN trial (NCT01237119), a phase 2 randomized controlled study enrolling 52 adults with biopsy-proven MASH [22]