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doi: 10.1001/jamanetworkopen.2023.17023 13
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After promising results, large-scale Phase III trials (the SUSTAIN program) were launched around 2015
Common reasons include: metabolic adaptation as the body becomes more efficient reduced calorie deficit as weight decreases appetite hormones adjusting over time changes in body composition lifestyle factors such as sleep and stress When progress slows, adjusting treatment may help support continued results
Benefits: *increases energy *increases B12 intake for vegans *increases mood *decreases depression symptoms Risks when deficient: Watch Video *increases dementia *decreases visual acuity Vitamin B12 is also used for various health and wellness applications like boosting red blood cell production, and helping to regulate sleep, mood, and appetite cycles
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Weight loss and physical performance Excess weight directly impairs sexual performance in ways that are both obvious and subtle
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