It was approved in 1959, making it the oldest FDA-approved weight-loss medication still on the market, and has traditionally been the most commonly prescribed anti-obesity drug in the United States, according to the Obesity Medicine Association
Wu , Michael Snyder Stanford Cardiovascular Institute #Longevity #Metformin #Omega3 #Exercise #Apelin #MetabolicHealth C-Level Biopharma Executive & Entrepreneur | Advisor in Formulation Development/CMC & Drug Delivery | Translational Drug Development Key Findings of A Major Diabetes Clinical Trial: - No Direct Reversal: After 26 weeks, metformin failed to improve insulin resistance in the liver, muscle, or adipose (fat) tissues of adults with Type 1 diabetes

In studies lasting 68 weeks, participants taking 412mg daily sometimes showed improved endurance, higher time-to-exhaustion scores, or smaller increases in creatine kinase an enzyme that rises with muscle damage.32 Not all trials find performance benefits, but those that do often include participants with lower baseline antioxidant intake or higher training loads.33 For now, researchers interpret the findings as preliminary evidence that astaxanthin may support recovery in situations where oxidative stress is high.38 Sleep and fatigue Researchers have begun exploring how carotenoid intake might relate to sleep quality
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At this stage, no GLP1 drug is FDAapproved specifically for reducing alcohol use
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