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10.1186/gb-2011-12-6-r60 35 ShimizuM.AllerstonC
What are the biological factors that contribute to weight gain
Interestingly, in echidna GLP-1 there is less conservation of the receptor binding residues with additional changes at the N-terminal receptor binding Phe 12 (conservatively substituted to Tyr) and Asp 15 (changed to Glu) residues
Growth hormone can push insulin sensitivity in the other direction