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Research published in the New England Journal of Medicine (NEJM), shows that over a 40-week trial participants taking orforglipron reduced their glycated haemoglobin levels significantly more than those on a placebo

Its said the most common side effects reported in the clinical trials were nausea, diarrhea, vomiting, decreased appetite, dyspepsia (acid reflux and related conditions) and constipation

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Yes, they are generally very safe when given by trained professionals