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The estimated difference between the semaglutide group and the placebo group in the change in the KCCQ-CSS was 5.3 points (95% CI, 0.2 to 10.7) among participants who received SGLT2 inhibitor therapy at baseline and 8.3 points (95% CI, 4.5 to 12.1) among those who did not receive SGLT2 inhibitor therapy at baseline

Studinski AL, Pino GB, Grycki E, et al

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They alter the entire metabolic environment

This work suggests that we may have overlooked a third phase, perhaps the most challenging one: maintaining the result over the long term

This means your skin doesn't just look better on the surface