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Ghosh AK, Mau T, OBrien M, Garg S, Yung R
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The disconnect between short plasma half-life and prolonged therapeutic effects observed in many studies supports tissue-level mechanisms extending beyond circulating peptide concentrations
Antioxidant action to protect the cells
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Since 90% of the bodys serotonin originates in the gut, these peripheral effects could influence central serotonergic tone through vagal signaling
& Vogel, V
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