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In the SURMOUNT-1 trial, patients without diabetes treated with tirzepatide 15 mg achieved a mean weight reduction of 16.0% at 72 weeks [22], while semaglutide 2.4 mg in the STEP-1 trial yielded a 14.9% reduction over a similar period (treatment regimen estimand) [23]
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Tirzepatide may offer the potential for greater weight loss compared to Ozempic due to its dual action on multiple hormonal pathways involved in appetite regulation and metabolism
-cell mitochondria therefore need to appropriately adapt to glucolipotoxic conditions to avoid progression towards overt T2D 72
A stronger effect may also bring stronger side effects
The Canadian regulatory environment differs somewhat from the United States, with Health Canada maintaining its own approval timeline
there was no significant difference in either body-weight gain or total food intake (per g body weight) among four experimental groups (data not shown)
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