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This specific ICV dose was empirically derived from a systemic equivalent of 10 mg/kg, adjusted based on the approximate brain-to-body weight ratio of a mouse, approximately 1:100
Sublingual Glutathione Sublingual supplements are designed to dissolve under the tongue
Even at 10x the effective dose, it barely touches those off-target hormones
W.LoebR
For example, researchers often pair it with SS-31 (elamipretide), a compound specifically designed to improve mitochondrial membrane integrity and ATP production
On the antioxidant side, Vitamin C and glutathione have a "recycling" relationship
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