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Semaglutide achieves roughly 15%, tirzepatide reaches about 22%, and retatrutide pushes past 28% in the latest Phase 3 data
That pressure, combined with relaxed lower esophageal tone (another GLP-1 effect observed in animal models), makes reflux and belching more likely regardless of food content
FDA Letter- Retatrutide
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Interestingly, impairment of carnitine absorption in calorie-restricted rats probably attenuates the carnitine concentration increment induced by repeated dietary L-carnitine administration during calorie restriction
We can now confidently say we have a drug that matches bariatric surgery outcomes
