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Your digestion suffers

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To raise your blood pressure, your body might trigger thirst signals, prompting you to drink more water

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They are all small molecules which act as reversible competitive inhibitors of the catalytic activity of DPP-4 and, when used at the appropriate therapeutic dose, are associated with at least 70% inhibition of plasma DPP-4 activity (35) (although the actual extent of inhibition in vivo is likely to be higher, due to dilution of the inhibitor in the ex vivo assay)

This amount helps keep B12 levels up, vital for nerves