Pineal peptides work best as part of a comprehensive sleep optimization strategy that includes appropriate light exposure (bright in morning, dim in evening), consistent sleep-wake times, cool sleeping environment (65 to 68 degrees Fahrenheit), limited stimulants after noon, and reduced screen exposure before bed
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[7] [9] Caution is advised in individuals with renal insufficiency or those on dialysis, as impaired clearance may increase the risk of accumulation and toxicity
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