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It was suggested that the strong anti-neuroinflammatory activity of the fresh ginger extract was largely contributed by 10-gingerol (Ho et al., 2013)
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Additionally, a randomized, double-blind, placebo-controlled trial in 2,588 healthy older adults with mild hyperhomocysteinemia found that daily supplementation with 500 g of vitamin B 12 and 400 g of folic acid for two years reduced blood homocysteine concentrations but had no benefit on depressive symptoms in those with or without depressive symptoms at baseline (110)
B12 is in animal products like meat, fish, and dairy
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