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Consultation with a hepatologist or endocrinologist experienced in managing complex cases is advisable before prescribing semaglutide to patients with decompensated cirrhosis

Start with lower concentrations to assess tolerance, then increase if needed

Patients see a smaller waistline, less deep abdominal fat, and preserved muscle

FDA-approved tirzepatide, sold as Mounjaro for type 2 diabetes and Zepbound for weight management, is a clear, colorless to slightly yellow solution

It works as a GLP-1 receptor agonist, mimicking the GLP-1 hormone to slow gastric emptying, stimulate insulin production, inhibit glucagon, and act on appetite-regulating centers in the brain

One of the major sources of non-essential amino acids is dietary, either as free amino acids or from the digestion of dietary proteins