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DMB, 3,3-dimethyl-1-butanol) to reduce TMAO levels and are being tested in models of cardiovascular diseases [271, 272]

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doi: 10.1080/03007995.2022.2081454 138 LemogneCGouraudCPitronVRanqueB

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Abbreviations AC: Adenylyl cyclase BCA: Bicinchoninic acid cAMP: Cyclic adenosine monophosphate CREB: Cyclic adenosine monophosphate response element-binding protein ER: Endoplasmic reticulum GAPDH: Glyceraldehyde 3-phosphate dehydrogenase GLP-1: Glucagon-like peptide-1 GLP-1R: Glucagon-like peptide-1 receptor HPRT1: Hypoxanthine phosphoribosyl transferase 1 HRP: Horseradish peroxidase IL-1: Interleukin-1 beta OA: Osteoarthritis PI3K: Phosphoinositide 3-kinase PKA: Protein kinase A RIPA: Radio immunoprecipitation assay ROS: Reactive oxygen species TNF-: Tissue Necrosis Factor-alpha References Huang K, Wu LD